Improvement of Primary Writing Tremor in Parkinson’s Disease with Carbidopa/Levodopa

نویسندگان

  • James P. Battista
  • Paul E. Greene
  • Elan D. Louis
چکیده

BACKGROUND Primary writing tremor is a task-specific phenomenon that has been described as variants of essential tremor or dystonia. PHENOMENOLOGY SHOWN We describe the case of a 63-year-old female who initially had primary writing tremor, later developed Parkinson's disease, and once initiated on carbidopa/levodopa had improvement in her parkinsonism and her writing tremor. EDUCATIONAL VALUE As neither essential tremor nor typical brachial dystonia respond to carbidopa/levodopa, our case documents that at least some cases of primary writing tremor are not variants of either dystonia or essential tremor.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Analogs of Carbidopa: in Silico Design & Development of Novel Dopa Decarboxylase Inhibitors in the Treatment of Parkinson’s Disease

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Pharmacotherapy with levodopa in combination with carbidopa provides symptomatic relief in patients suffering from PD. However, several studies have been conducted in an attempt to improve the therapeutic efficiency of levodopa by using drugs that preferentially inhibit extracerebral decarboxylase. Yet, none of them ...

متن کامل

TRANSLATIONAL PHYSIOLOGY Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle

Smith, Jill L., Jeong-Sun Ju, Bithika M. Saha, Brad A. Racette, and Jonathan S. Fisher. Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle. J Appl Physiol 97: 2339–2346, 2004; doi:10.1152/japplphysiol.01219.2003.—We hypothesized that levodopa with carbidopa, a common therapy for patients with Par...

متن کامل

Effects of Repeated Bouts of Segmental Vibration Therapy on Balance in Parkinson’s Disease

In 2005, the incidence of Parkinson’s disease (PD) in the world’s most populous nations was estimated to be 4.1 million people [1]. Furthermore, it is predicted that by the year 2030 more than 8 million people in these countries will develop this disease [1]. PD is progressive and, over time, symptoms can become increasingly severe. There are four cardinal symptoms including tremor at rest, rig...

متن کامل

Pharmacokinetics of Rytary®, An Extended-Release Capsule Formulation of Carbidopa–Levodopa

Parkinson's disease (PD) is a chronic progressive neurological disorder characterized by resting tremor, rigidity, bradykinesia, gait disturbance, and postural instability. Levodopa, the precursor to dopamine, coadministered with carbidopa or benserazide, aromatic amino acid decarboxylase inhibitors, is the most effective and widely used therapeutic agent in the treatment of PD. With continued ...

متن کامل

Levodopa-Responsive Benign Tremulous Parkinsonism

BACKGROUND Benign tremulous parkinsonism (BTP) is a tremor dominant syndrome characterized by mild, levodopa-resistant parkinsonism with limited disability or progression. CASE PRESENTATION A 56-year-old woman presented with a 2-year history of tremor. Neurological examination revealed right-hand rest tremor and slow finger tapping with decreased amplitude; however, we did not observe posture...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2015